Dr. Susanne Holtze


Department of Reproduction Management

Tel: 0049 (0) 30 5168 - 436
E-Mail: holtze@izw-berlin.de

Short curriculum vitae

Dr. Susanne Holtze studied biology at Freie Universität Berlin, conducted her master’s thesis at the University of Queensland in Brisbane, Australia. For her doctorate, she worked at Charité Berlin and the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig. She obtained a degree in veterinary medicine from Freie Universität Berlin. Since 2012, she has been working as a postdoctoral researcher at the Leibniz-IZW focusing on ageing research as well as assisted reproductive technologies (ART) in endangered species.

Research interests
  • Reproduction management
  • Animal reproduction and medicine
  • Assisted reproductive technology (ART)
  • Physiology of naked mole rats
  • Aging research
  • Imaging techniques, particularly ultrasonography
Selected publications

Vays V, Vangely I, Eldarov C, Popkov V, Holtze S, Hildebrandt T, Averina OA, Bakeeva L, Zorov D. (2022). Unique features of the tissue structure in the naked mole rat (Heterocephalus glaber): hypertrophy of the endoplasmic reticulum and spatial mitochondrial rearrangements in hepatocytes. Int. J. Mol. Sci. 23, 9067, 1-15.

Szafranski K, Wetzel M, Holtze S, Büntjen I, Lieckfeldt D, Ludwig A, Huse K, Platzer M, Hildebrandt TB. (2022). The mating pattern of captive naked mole-rats is best described by a monogamy model. Frontiers Ecology and Evolution 10, 1-9.

Vays V, Vangely I, Eldarov C, Holtze S, Hildebrandt T, Bakeeva L, Skulachev V. (2021). Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats (Heterocephalus glaber) as revealed by electron microscopy: potential role in continual maintenance of muscle activity. Aging (Albany NY). 13:24524-24541. doi: 10.18632/aging.203720.

Holtze S, Gorshkova E, Braude S, Cellerino A, Dammann P, Hildebrandt TB,  Hoeflich A, Hoffmann S, Koch P, Terzibasi Tozzini E, Skulachev M, Skulachev VP, Sahm A. (2021). Alternative animal models of aging research. Frontiers in Molecular Biosciences, 8, 311. Accepted for publication 08.04.2021.

Hildebrandt TB, Hermes R, Goeritz F, Appeltant R, Colleoni S, de Mori B, Diecke S, Drukker M, Galli C, Hayashi K, Lazzari G, Loi P, Payne J, Renfree M, Seet S, Stejskal J, Swegen A, Williams SA, Zainuddin ZZ, Holtze S.  (2021). The ART of bringing extinction to a freeze - History and future of species conservation, exemplified by rhinos. Theriogenology. 169:76-88. doi: 10.1016/j.theriogenology.2021.04.006. Epub 2021 Apr 18. PMID: 33940218.

Zucca P, Rossmann MC, Dodic M, Ramma Y, Matsushima T, Seet S, Holtze S, Bremini A, Fischinger I, Morosetti G, Sitzia M, Furlani R, Greco O, Meddi G, Zambotto P, Meo F, Pulcini S, Palei M, Zamaro G. (2021). What Do Adolescents Know About One-Health and Zoonotic Risks? A School-Based Survey in Italy, Austria, Germany, Slovenia, Mauritius, and Japan. Front Public Health. 9:658876. doi: 10.3389/fpubh.2021.658876

Del Marmol D, Holtze S, Kichler N, Sahm A, Bihin B, Bourguignon V, Dogné S, Szafranski K, Hildebrandt TB, Flamion B. (2021). Abundance and size of hyaluronan in naked mole-rat tissues and plasma. Scientific Reports 11,7951. doi: 10.1038/s41598-021-86967-9. PMID: 33846452.

Hildebrandt TB*, Holtze S*, Biasetti P, Colleoni S, de Mori B, Diecke S, Göritz F, Hayashi K, Hayashi M, Hermes R, Kariuki L, Lazzari G, Mijele D, Mutisya S, Ndeereh D, Ngulu S, Seet S, Zwilling J, Zywitza V, Stejskal J, Galli C. (2021). Conservation Research in Times of COVID-19–The Rescue of the Northern White Rhino. J APPL ANIM ETH RES. 20,1–22. doi:10.1163/25889567-BJA10009

de Mori B, Spiriti MM, Pollastri I, Normando S, Biasetti P, Florio D, Andreucci F, Colleoni S, Galli C, Göritz F, Hermes R, Holtze S, Lazzari G, Seet S, Zwilling J, Stejskal J, Mutisya S, Ndeereh D, Ngulu S, Vigne R, Hildebrandt TB.  (2021). An Ethical Assessment Tool (ETHAS) to Evaluate the Application of Assisted Reproductive Technologies in Mammals’ Conservation: The Case of the Northern White Rhinoceros (Ceratotherium simum cottoni). ANIMALS. 11, 312. doi:10.3390/ani11020312

Walz M, Höflich C, Walz C, Ohde D, Brenmoehl J, Sawitzky M, Vernunft A, Zettl UK, Holtze S, Hildebrandt TB, Wolf E, Hoeflich A. (2021). Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices. Cells 10, 482. doi: 10.3390/cells10030482. PMID: 33668197; PMCID: PMC7995968.

Braude S*, Holtze S*, Begall S, Brenmoehl J, Burda H, Dammann P, Del Marmol D, Gorshkova E, Henning Y, Hoeflich A, Höhn A, Jung T, Hamo D, Sahm A, Shebzukhov Y, Šumbera R, Miwa S, Vyssokikh MY, von Zglinicki T, Averina O, Hildebrandt TB. (2021). Surprisingly long survival of premature conclusions about naked mole-rat biology. BIOL REV 96, 376–393. doi:10.1111/brv.12660

Holtze S, Koch R, Hildebrandt TB, Lemma A, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Braude S. (2020). Hematologic adaptation to the subterranean environment by the naked mole-rat, Heterocephalus glaber (Ctenohystrica: Heterocephalidae). J MAMMAL. 101, 1000-9. doi.org/10.1093/jmammal/gyaa053

Braude S, Holtze S, Hildebrandt T, Koch R. (2020). Naked mole‐rats do not disperse or deliver pups in correlation with moon phase. AFR J ECOL, 00, 1–4. doi: 10.1111/aje.12721.

Eldarov CM, Vangely IM, Vays VB, Sheval EV, Holtze S, Hildebrandt TB, Kolosova NG, Popkov VA, Plotnikov EY, Zorov DB, Bakeeva LE, Skulachev VP. (2020). Mitochondria in the Nuclei of Rat Myocardial Cells. CELLS 9, 712. doi: 10.3390/cells9030712. PMID: 32183238.

Vyssokikh MY, Holtze S, Averina OA, Lyamzaev KG, Panteleeva AA, Marey MV, Zinovkin RA, Severin FF, Skulachev MV, Fasel N, Hildebrandt TB, Skulachev VP. (2020). Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program. PNAS, 117, 6491-6501. doi: 10.1073/pnas.1916414117.

Carmeli-Ligati S, Shipov A, Dumont M, Holtze S, Hildebrandt T, Shahar R (2019). The structure, composition and mechanical properties of the skeleton of the naked mole-rat (Heterocephalus glaber). BONE. 128:115035. doi:10.1016/j.bone.2019.115035.

Shebzukhov Y, Holtze S, Hirseland H, Schäfer H, Radbruch A, Hildebrandt T, Grützkau A (2019). Identification of cross‐reactive antibodies for the detection of lymphocytes, myeloid cells and haematopoietic precursors in the naked mole rat. EUR J IMMUNOL. doi: 10.1002/eji.201948124.

Hermes R, Hildebrandt TB, Göritz F, Fasel NJ, Holtze S (2019). First cryopreservation of phyllostomid bat sperm. THERIOGENOLOGY. 131:28-31. doi: 10.1016/j.theriogenology.2019.03.014. Epub 2019 Mar 19. PMID: 30933687

Bens M, Szafranski K, Holtze S, Sahm A, Groth M, Kestler HA, Hildebrandt TB, Platzer M (2018). Naked mole-rat transcriptome signatures of socially-suppressed sexual maturation and links of reproduction to aging. BMC BIOL. 16:77. doi: 10.1186/s12915-018-0546-z.

Hildebrandt TB, Hermes R, Colleoni S, Diecke S, Holtze S, Renfree M, Stejskal J, Hayashi K, Drukker M, Loi P, Göritz F, Lazzari G, Galli C (2018). Embryos and embryonic stem cells from the white rhinoceros. NAT COMMUN 9:2589. doi: 10.1038/s41467-018-04959-2.

Holtze S, Lukač M, Cizelj I, Mutschmann F, Szentiks CA, Jelić D, Hermes R, Göritz F, Braude S, Hildebrandt TB (2017). Monitoring health and reproductive status of olms (Proteus anguinus) by ultrasound. PLOS ONE, 12(8), e0182209.

Skulachev VP*, Holtze S*, Vyssokikh MY, Bakeeva LE, Skulachev MV, Markov AV, Hildebrandt TB**, Sadovnichii VA** (2017). Neoteny, Prolongation of Youth: From Naked Mole Rats to "Naked Apes" (Humans). PHYSIOL REV, 97:699-720.

Holtze S, Braude S, Lemma A, Koch R, Morhart M, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Hildebrandt TB (2017). The microenvironment of naked mole-rat burrows in East Africa. AFR J ECOL 56, 279-289.

Saragusty J, Diecke S, Drukker M, Durrant B, Friedrich Ben-Nun I, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring J, Okita K, Renfree M, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB (2016). Rewinding the process of mammalian extinction. ZOO BIOL, 35, 280-292.

Holtze S, Eldarov CM, Vays VB, Vangeli IM, Vysokikh MY, Bakeeva LE, Skulachev VP, Hildebrandt TB (2016). Study of Age-Dependent Structural and Functional Changes of Mitochondria in Skeletal Muscles and Heart of Naked Mole Rats (Heterocephalus glaber). BIOCHEMISTRY (Mosc). 81,429-1437.

Amitai O*, Holtze S*, Barkan S*, Amichai E*, Korine C, Pinshow B, Voigt CC. (2010). Fruit bats (Pteropodidae) fuel their metabolism rapidly and directly with exogenous sugars. J EXP BIOL 213, 2693 - 2699.