Dr. Shuai Chen

Senior scientist

Department of Reproduction Biology


Tel: 0049 (0) 30 5168 - 617

short curriculum vitae

  • 2021-now: Senior scientist, Department of Reproductive Biology, Leibniz-IZW
  • 2019-2021: Research scientist, Institute of Reproductive Biology, FBN Dummerstorf
  • 2017-2018: Leibniz-Mentoring Program for Female Scholars at Leibniz Institutes
  • 2014-2019: Postdoc (Tenure Track), Institute of Reproductive Biology, FBN Dummerstorf
  • 2013-2015: Associate professor at the College of Life Sciences, Hebei University
  • 2010-2013: PhD degree, Biomedical Sciences, Freie Universität Berlin

functional biodiversity of cells belonging to the reproductive system

Biobanking for assisted reproduction techniques

Dialogue(s) for fertility: deciphering spermatozoa-oviduct interactions and their implications for artificial insemination in cattle

Fertility impairment by maternal stress:

Using a novel 3D in vitro system to decipher the impact of cortisol on oviduct epithelium physiology, oviduct-derived extracellular vesicles and early embryonic development

Research interests
  • 3D cell culture models
  • Embryo/gamete-maternal interaction
  • Assisted reproductive technologies
  • Extracellular vesicles in reproduction
  • Hormonal actions in the female reproductive tract
Selected publications
  1. Chen S, Schoen J. Using the Air-Liquid Interface Approach to Foster Apical-Basal Polarization of Mammalian Female Reproductive Tract Epithelia In Vitro. Methods Mol Biol. 2021, 2273:251-262. http://dx.doi.org/10.1007/978-1-0716-1246-0_18.
  2. Du S, Trakooljul N, Schoen J, Chen S. Does Maternal Stress Affect the Early Embryonic Microenvironment? Impact of Long-Term Cortisol Stimulation on the Oviduct Epithelium. Int J Mol Sci. 2020;21(2):443.
  3. Laezer I, Palma-Vera SE, Liu F, Frank M, Trakooljul N, Vernunft A, Schoen J, Chen S. Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period. Reproduction. 2020;159 (4): 371-382.
  4. Saint-Dizier M, Schoen J, Chen S, Banliat C, Mermillod P. Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions. Int J Mol Sci. 2019;21(1):223.
  5. Chen S, Schoen J. Air-liquid interface cell culture: from airway epithelium to the female reproductive tract. Reprod Domest Anim. 2019; 54 Suppl 3:38-45.
  6. Schoen J, Chen S. Das Eileiterepithel in vitro. In: Der Ovidukt – ein wenig beachtetes Organ am Beginn jedes Wirbeltierlebens (Nova Acta Leopoldina, NF, 422) (Gottfried Brem, Hrsg.) Halle 2019; (978-3-8047-3991-8): 115-130.
  7. Chen S, Palma-Vera SE, Kempisty B, Rucinski M, Vernunft A, Schoen J. In Vitro Mimicking of Estrous Cycle Stages: Dissecting the Impact of Estradiol and Progesterone on Oviduct Epithelium. Endocrinology. 2018;159(9):3421-3432.
  8. Schoen J, Chen S. Modeling early embryo-maternal interactions in vitro. Animal Reproduction. 2018;15:784-790.
  9. Théry C, Witwer KW,..., Chen S, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles.2018; 8 (1): 1535750, 1-43.
  10. Chen S, Palma-Vera SE, Langhammer M, Galuska SP, Braun B, Krause E, Lucas-Hahn A, Schoen J. An air-liquid interphase approach for modeling the early embryo-maternal contact zone. Sci Rep. 2017;7:42298.
  11. van der Weijden VA*, Chen S*, Bauersachs S, Ulbrich SE, Schoen J. Gene expression of bovine embryos developing at the air-liquid interface on oviductal epithelial cells (ALI-BOEC). Reprod Biol Endocrin. 2017;15.
  12. Palma-Vera SE, Schoen J, Chen S. Periovulatory follicular fluid levels of estradiol trigger inflammatory and DNA damage responses in oviduct epithelial cells. PLoS One. 2017;12(2):e0172192.
  13. Chen S, Einspanier R, Schoen J. Transepithelial electrical resistance (TEER): a functional parameter to monitor the quality of oviduct epithelial cells cultured on filter supports. Histochem Cell Biol. 2015;144(5):509-515.
  14. Yu X, Wang N, Qiang R, Wan Q, Qin M, Chen S, Wang H. Human Amniotic Fluid Stem Cells Possess the Potential to Differentiate into Primordial Follicle Oocytes In Vitro.
    Biol Reprod. 2014; 90(4): 73.
  15. Chen S, Einspanier R, Schoen J. In vitro mimicking of estrous cycle stages in porcine oviduct epithelium cells: estradiol and progesterone regulate differentiation, gene expression, and cellular function. Biol Reprod. 2013;89(3):54.
  16. Chen S, Einspanier R, Schoen J. Long-term culture of primary porcine oviduct epithelial cells: validation of a comprehensive in vitro model for reproductive science. Theriogenology. 2013;80(8):862-869.