Dr. Shuai Chen

Scientist

Department of Reproduction Biology

 

Tel: 0049 (0) 30 5168 - 617
 

short curriculum vitae

  • 2021-now: Senior scientist, Department of Reproductive Biology, Leibniz-IZW
  • 2019-2021: Research scientist, Institute of Reproductive Biology, FBN Dummerstorf
  • 2017-2018: Leibniz-Mentoring Program for Female Scholars at Leibniz Institutes
  • 2014-2019: Postdoc (Tenure Track), Institute of Reproductive Biology, FBN Dummerstorf
  • 2013-2015: Associate professor at the College of Life Sciences, Hebei University
  • 2010-2013: PhD degree, Biomedical Sciences, Freie Universität Berlin
Download detailed curriculum vitae
Projects
Research interests
  • 3D cell culture models
  • Embryo/gamete-maternal interaction
  • Assisted reproductive technologies
  • Extracellular vesicles in reproduction
  • Hormonal actions in the female reproductive tract
Selected publications
  1. Huo J, Mówińska AM, Eren AN, Schoen J, Chen S (2024): Oxygen levels affect oviduct epithelium functions in air–liquid interface culture. HISTOCHEM CELL BIOL, 161, 521–537. doi:10.1007/s00418-024-02273-1.
  2. Welsh JA, Goberdhan DCI, O’Driscoll L, …, MISEV Consortium (IZW co‐author: Chen S), Théry C, Witwer KW (2024): Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J EXTRACELL VESICLES 13, e12404. doi:10.1002/jev2.12404.
  3. Du S, Trakooljul N, Palma‐Vera SE, Murani E, Schuler G, Schön J, Chen S (2023): Regulation of porcine oviduct epithelium functions via progesterone and estradiol is influenced by cortisol. ENDOCRINOLOGY 164, bqac176. doi:10.1210/endocr/bqac176.
  4. Eder S, Müller K, Chen S, Schön J (2022): Long‐term culture of feline oviduct epithelial cells on permeable filter supports. CYTOTECHNOLOGY 74, 531–538. doi:10.1007/s10616-022-00542-2.
  5. Chen S, Schoen J. Using the Air-Liquid Interface Approach to Foster Apical-Basal Polarization of Mammalian Female Reproductive Tract Epithelia In Vitro. Methods Mol Biol. 2021, 2273:251-262. http://dx.doi.org/10.1007/978-1-0716-1246-0_18.
  6. Du S, Trakooljul N, Schoen J, Chen S. Does Maternal Stress Affect the Early Embryonic Microenvironment? Impact of Long-Term Cortisol Stimulation on the Oviduct Epithelium. Int J Mol Sci. 2020;21(2):443. https://doi.org/10.3390/ijms21020443.
  7. Laezer I, Palma-Vera SE, Liu F, Frank M, Trakooljul N, Vernunft A, Schoen J, Chen S. Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period. Reproduction. 2020;159 (4): 371-382. https://doi.org/10.1530/REP-19-0219.
  8. Saint-Dizier M, Schoen J, Chen S, Banliat C, Mermillod P. Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions. Int J Mol Sci. 2019;21(1):223. https://doi.org/10.3390/ijms21010223.
  9. Chen S, Schoen J. Air-liquid interface cell culture: from airway epithelium to the female reproductive tract. Reprod Domest Anim. 2019; 54 Suppl 3:38-45. https://doi.org/10.1111/rda.13481.
  10. Schoen J, Chen S. Das Eileiterepithel in vitro. In: Der Ovidukt – ein wenig beachtetes Organ am Beginn jedes Wirbeltierlebens (Nova Acta Leopoldina, NF, 422) (Gottfried Brem, Hrsg.) Halle 2019; (978-3-8047-3991-8): 115-130.
  11. Chen S, Palma-Vera SE, Kempisty B, Rucinski M, Vernunft A, Schoen J. In Vitro Mimicking of Estrous Cycle Stages: Dissecting the Impact of Estradiol and Progesterone on Oviduct Epithelium. Endocrinology. 2018;159(9):3421-3432. https://doi.org/10.1210/en.2018-00567.
  12. Schoen J, Chen S. Modeling early embryo-maternal interactions in vitro. Animal Reproduction. 2018;15:784-790. http://dx.doi.org/10.21451/1984-3143-AR2018-0012.
  13. Théry C, Witwer KW,..., Chen S, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles.2018; 8 (1): 1535750, 1-43. https://doi.org/10.1080/20013078.2018.1535750.
  14. Chen S, Palma-Vera SE, Langhammer M, Galuska SP, Braun B, Krause E, Lucas-Hahn A, Schoen J. An air-liquid interphase approach for modeling the early embryo-maternal contact zone. Sci Rep. 2017;7:42298. https://doi.org/10.1038/srep42298.
  15. van der Weijden VA*, Chen S*, Bauersachs S, Ulbrich SE, Schoen J. Gene expression of bovine embryos developing at the air-liquid interface on oviductal epithelial cells (ALI-BOEC). Reprod Biol Endocrin. 2017;15. https://doi.org/10.1186/s12958-017-0310-1.
  16. Palma-Vera SE, Schoen J, Chen S. Periovulatory follicular fluid levels of estradiol trigger inflammatory and DNA damage responses in oviduct epithelial cells. PLoS One. 2017;12(2):e0172192. https://doi.org/10.1371/journal.pone.0172192.
  17. Chen S, Einspanier R, Schoen J. Transepithelial electrical resistance (TEER): a functional parameter to monitor the quality of oviduct epithelial cells cultured on filter supports. Histochem Cell Biol. 2015;144(5):509-515. https://doi.org/10.1007/s00418-015-1351-1.
  18. Yu X, Wang N, Qiang R, Wan Q, Qin M, Chen S, Wang H. Human Amniotic Fluid Stem Cells Possess the Potential to Differentiate into Primordial Follicle Oocytes In Vitro.
    Biol Reprod. 2014; 90(4): 73. https://doi.org/10.1095/biolreprod.113.112920.
  19. Chen S, Einspanier R, Schoen J. In vitro mimicking of estrous cycle stages in porcine oviduct epithelium cells: estradiol and progesterone regulate differentiation, gene expression, and cellular function. Biol Reprod. 2013;89(3):54. https://doi.org/10.1095/biolreprod.113.108829.
  20. Chen S, Einspanier R, Schoen J. Long-term culture of primary porcine oviduct epithelial cells: validation of a comprehensive in vitro model for reproductive science. Theriogenology. 2013;80(8):862-869. https://doi.org/10.1016/j.theriogenology.2013.07.011.