Dr. Karin Müller

Wissenschaftliche Mitarbeiterin

Abteilung für Reproduktionsbiologie

 

Tel: 0049 (0) 30 5168 - 613
 
 

Kurzer Lebenslauf

Karin Müller ist seit 2007 Wissenschaftlerin der Abteilung Reproduktionsbiologie. Ihr fachliches Interesse gilt der Reproduktionsbiologie der männlichen Keimzellen sowie der Gefrierkonservierung. Insbesondere die physiologische Rolle von Lipiden und Seminalplasma bei der Befruchtung sind Gegenstand der Forschung.
 
Projekte
Forschungsinteressen

- Charakterisierung von Spermatogenese und Spermienfunktion

- (Kryo-)Konservierung von Spermien und Hodengewebe

- Analyse der Lipid-Zusammensetzung und -Organisation der Spermienmembranen

- Interaktion von Spermien, Seminalplasma und weiblichem Genitaltrakt

- Fluoreszenzmikroskopische Methoden  

Ausgewählte Publikationen

Bajerski F, Bürger A, Glasmacher B, Keller ERJ, Müller K, Mühldorfer K, Nagel M, Rüdel H, Müller T, Schenkel J, Overmann J (2020): Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples. APPL MICROBIOL BIOTECHNOL 104, 131–144. doi:10.1007/s00253-019-10242-1

Bashawat M, Braun BC, Müller K (2020): Cell survival after cryopreservation of dissociated testicular cells from feline species. CRYOBIOLOGY 97, 191–197. doi:10.1016/j.cryobiol.2020.03.001

Diemer J, Hahn J, Goldenbogen B, Müller K, Klipp E (2020): Sperm migration in the genital tract - in silico experiments identify key factors for reproductive success. BIORXIV. doi:10.1101/2020.03.05.977967

Eder S, Bailey LD, Müller K (2020): Equilibration in freezing extender alters in vitro sperm-oviduct binding in the domestic cat (Felis catus). THERIOGENOLOGY 149, 79–87. doi:10.1016/j.theriogenology.2020.03.017

Engel KM, Jakop U, Müller K, Grunewald S, Paasch U, Schiller J (2020): MALDI MS analysis to investigate the lipid composition of sperm. CURRENT ANALYTICAL CHEMISTRY 16, 79-91. doi:10.2174/1573411014666181030123256

Müller K, Eder S, Jakop U, Schiller J, Müller P, Bashawat M (2020): Assisted reproduction for felid species conservation – sperm competences at risk. REPROD DOMEST ANIM 55, 55–60. doi:10.1111/rda.13581

Schulze M, Jakop U, Schröter F, Herrmann C, Leiding C, Müller K, Jung M, Czirják GÁ (2020): Antibacterial defense in bull and boar semen: a putative link to the microbiome and reproductive strategy? THERIOGENOLOGY 157, 335–340. doi:10.1016/j.theriogenology.2020.07.033

Fasel NJ, McMillian K, Jakop U, Mene-Saffrane L, Engel KM, Genoud M, Müller K, Christe P (2019): Modification of sperm fatty acid composition during epididymal maturation in bats. REPRODUCTION 157, 77–85. doi:10.1530/REP-18-0463

Fernandez-Gonzalez L, Müller K, Jewgenow K, Zahmel J (2019): Felid-gamete-rescue within EAZA – efforts and results in biobanking felid oocytes and sperm. J ZOO AQUAR RES 7, 15–24. doi:10.19227/jzar.v7i1.369

Jakop U, Svetlichnyy V, Schiller J, Schulze M, Schroeter F, Müller K (2019): In vitro supplementation with unsaturated fatty acids improves boar sperm viability after storage at 6 °C. ANIM REPROD SCI 206, 60–68. doi:10.1016/j.anireprosci.2019.05.008

Schulze M, Czirják GÁ, Müller K, Bortfeldt R, Jung M, Jakop U (2019): Antibacterial defense and sperm quality in boar ejaculates. J REPROD IMMUNOL 131, 13–20. doi:10.1016/j.jri.2018.11.001

Braun BC, Okuyama MW, Müller K, Dehnhard M, Jewgenow K (2018): Steroidogenic enzymes, their products and sex steroid receptors during testis development and spermatogenesis in the domestic cat (Felis catus). J STEROID BIOCHEM MOL BIOL 178, 135–149. doi:10.1016/j.jsbmb.2017.11.013

Wegener J, Jakop U, Schiller J, Müller K (2018): The membrane phospholipid composition of honeybee (Apis mellifera) workers reflects their nutrition, fertility and vitellogenin stores. INSECT SOC 65, 381–391. doi:10.1007/s00040-018-0623-x

Engel KM, Schiller J, Müller K, Dannenberger D, Jakop U (2017): The phospholipid composition of kangaroo spermatozoa verified by mass spectrometric lipid analysis. LIPIDS 52, 857–869. doi:10.1007/s11745-017-4283-9

Luther I, Jakop U, Lueders I, Tordiffe A, Franz C, Schiller J, Kotze A, Müller K (2017): Semen cryopreservation and radical reduction capacity of seminal fluid in captive African lion (Panthera leo). THERIOGENOLOGY 89, 295–304. doi:10.1016/j.theriogenology.2016.10.024

Schröter F, Müller K, Müller P, Krause E, Braun BC (2017): Recombinant expression of porcine spermadhesin AWN and its phospholipid interaction: indication for a novel lipid binding property. REPROD DOMEST ANIM 52, 585–595. doi:10.1111/rda.12953

Sowinska N, Müller K, Niżański W, Jewgenow K (2017): Mitochondrial characteristics in oocytes of the domestic cat (Felis catus) after in vitro maturation and vitrification. REPROD DOMEST ANIM 52, 806–813. doi:10.1111/rda.12982

Brütsch SH, Rademacher M, Roth SR, Müller K, Eder S, Viertel D, Franz C, Kühn H, Borchert A (2016): Male subfertility induced by heterozygous expression of catalytically inactive glutathione peroxidase 4 is rescued in vivo by systemic inactivation of the Alox15 gene. J BIOL CHEM 291, 23578–23588. doi:10.1074/jbc.M116.738930

Klaus C, Eder S, Franz C, Müller K (2016): Successful cryopreservation of domestic cat (Felis catus) epididymal sperm after slow equilibration to 15 or 10°C. REPROD DOMEST ANIM 51, 195–203. doi:10.1111/rda.12666

Schröter F, Jakop U, Teichmann A, Haralampiev I, Tannert A, Wiesner B, Müller P, Müller K (2016): Lipid dynamics in boar sperm studied by advanced fluorescence imaging techniques. EUR BIOPHYS J BIOPHYS LETT 45, 149–163. doi:10.1007/s00249-015-1084-z

Schulze M, Dathe M, Waberski D, Müller K (2016): Liquid storage of boar semen: Current and future perspectives on the use of cationic antimicrobial peptides to replace antibiotics in semen extenders. THERIOGENOLOGY 85, 39–46. doi:10.1016/j.theriogenology.2015.07.016

Tannert A, Otto S, Hoerold J, Jewgenow K, Mueller K (2016): Ultrasound-assisted cryopreservation of gametes. IIR International Workshop Cold Applications in Life Sciences, 08.–09.09.2016, Dresden, Germany, ID: 012. doi: 10.18462/iir.cals.2016.0012

Braun BC, Müller K, Jewgenow K (2015): Expression profiles of relaxin family peptides and their receptors indicate their influence on spermatogenesis in the domestic cat (Felis catus). DOMEST ANIM ENDOCRINOL 52, 25–34. doi:10.1016/j.domaniend.2015.01.005

Henry F, Eder S, Reynaud K, Schön J, Wibbelt G, Fontbonne A, Müller K (2015): Seminal fluid promotes in vitro sperm-oviduct binding in the domestic cat (Felis catus). THERIOGENOLOGY 83, 1373–1380. doi:10.1016/j.theriogenology.2015.01.031

Schulze M, Grobbel M, Müller K, Junkes C, Dathe M, Rüdiger K, Jung M (2015): Challenges and limits using antimicrobial peptides in boar semen preservation. REPROD DOMEST ANIM 50, Suppl 2:5-10. doi:10.1111/rda.12553

Lüders I, Ludwig C, Schröder M, Müller K, Zahmel J, Dehnhard M (2014): Successful non-surgical artificial insemination and hormonal monitoring in an Asiatic golden cat (Catopuma temmincki). J ZOO WILDL MED 45, 372–379. doi:10.1638/2013-0269r.1

Müller K, Koster S, Painer J, Söderberg A, Gavier-Widèn D, Dehnhard M, Jewgenow K (2014): Testosterone production and spermatogenesis in free-ranging Eurasian lynx (Lynx lynx) throughout the year. EUR J WILDL RES 60, 569–577. doi:10.1007/s10344-014-0821-4

Pyttel S, Nimptsch A, Böttger J, Zschörnig K, Jakop U, Wegener J, Müller K, Paasch U, Schiller J (2014): Changes of murine sperm phospholipid composition during epididymal maturation determined by MALDI-TOF mass spectrometry. THERIOGENOLOGY 82, 396–402. doi:10.1016/j.theriogenology.2014.04.017

Schulze M, Junkes C, Müller P, Speck S, Rüdiger K, Dathe M, Müller K (2014): Are cationic antimicrobial peptides an alternative for conventional antibiotics in boar semen preservation? Effects of antimicrobial peptides on liquid-preserved boar spermatozoa. PLOS ONE 9, e100490. doi:10.1371/journal.pone.0100490

Speck S, Courtiol A, Junkes C, Dathe M, Müller K, Schulze M (2014): Cationic synthetic peptides: assessment of their antimicrobial potency in liquid preserved boar semen. PLOS ONE 9, e105949. doi:10.1371/journal.pone.0105949

Svetlichnyy V, Müller P, Pomorski TG, Schulze M, Schiller J, Müller K (2014): Metabolic incorporation of unsaturated fatty acids into boar spermatozoa lipids and de novo formation of diacylglycerols. CHEM PHYS LIPIDS 177, 41–50. doi:10.1016/j.chemphyslip.2013.11.001

Nimptsch A, Fuchs B, Süß R, Zschörnig K, Jakop U, Göritz F, Schiller J, Müller K (2013): A simple method to identify ether lipids in spermatozoa samples by MALDI-TOF mass spectrometry. ANAL BIOANAL CHEM 405, 6675–6682. doi:10.1007/s00216-013-7147-z

Schulze M, Ruediger K, Müller K, Jung M, Well C, Reissmann M (2013): Development of an in vitro index to characterize fertilizing capacity of boar ejaculates. ANIM REPROD SCI 140, 70–76. doi:10.1016/j.anireprosci.2013.05.012

Simon P, Bäumner S, Busch O, Röhrich R, Kaese M, Richterich P, Wehrend A, Müller K, Gerardy-Schahn R, Mühlenhoff M, Geyer H, Geyer R, Middendorff R, Galuska SP (2013): Polysialic acid is present in mammalian semen as a post-translational modification of NCAM and the polysialyltransferase ST8SiaII. J BIOL CHEM 228, 18825–18833. doi:10.1074/jbc.M113.451112

Wegener J, Bresler K, Teuber K, Fuchs B, Schiller J, Müller K (2013): Conservation of honey bee (Apis mellifera) sperm phospholipids during storage in the bee queen – a TLC/MALDI-TOF MS Study. EXP GERONTOL 48, 213–222. doi:10.1016/j.exger.2012.12.009